CAR-M cell therapy refers to transferring the edited specific CAR gene to macrophages, so that it has the ability to bind to the surface of tumor cells through specific antigen identification and subsequently activate the activity of macrophages targeting tumor cells. The emergence of CAR-M opens up a new possibility for the treatment of solid tumors: to modify human macrophages with specific CAR to improve the phagocytic activity and antigen presentation of macrophages against tumors.